NIDA’s Clinical Trail’s Initiative (CTN) video provides an overview of Buprenorphine, a semi-synthetic opioid, used in the treatment of adults with opioid use disorder. The video highlights the opioid epidemic in the USA, the potential benefits and risks of the prescription of opioids for pain management including the risk of the development of opioid use disorder. Of the three approved medications for MAT, the video focuses on sublingual buprenorphine. The video provides a summary of buprenorphine formulations and actions, how to start a patient on buprenorphine as well as potential side effects including the risk of relapse and overdose when it is tapered.